Professor Zaida (Zan) Luthey-Schulten received a B.S. in Chemistry from the University of Southern California in 1969, an M.S. in Chemistry from Harvard University in 1972, and a Ph.D. in Applied Mathematics from Harvard University in 1975. From 1975 to 1980, she was a Research Fellow at the Max-Planck Institute for Biophysical Chemistry in Göttingen, and from 1980 to 1986, a Research Associate in the Department of Theoretical Physics at the Technical University of Munich. Professor Luthey-Schulten has been at the University of Illinois since 1987, where she is currently the Murchison-Malley Professor of Chemistry, co-director of the NSF Center for the Physics of Living Cells, and co-investigator at the NIH Resource of Macromolecular Modeling and Bioinformatics at the Beckman Institute.
Her research group currently develops the GPU-based software Lattice Microbes for spatially-resolved stochastic simulations of whole cells at biologically relevant length (micron), time (hours), and concentrations (nM to mM) scales. Their simulations of a minimal cell and simple eukaryotic cells integrate a broad range of experimental data with hybrid stochastic-deterministic methodologies to determine the time-dependence of metabolites, proteins, and nucleic acids involved in cellular processes of metabolism, genetic information processing, and growth.
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Suggested Reading or Key Publications:
- Recent May 2021 Nature Methods on Integrating Experiments, Theory, and Simulations into Whole Cell Models. https://doi.org/10.1038/s41592-021-01150-2
- Review article Stochastic Physics in Biology in Reports on Progress in Physics – 2018 https://doi.org/10.1088/1361-6633/aaae2c
- Stochastic modeling genetic information processing in the minimal cell – 2019 https://doi.org/10.3389/fmolb.2019.00130
- Essential metabolism of the minimal cell – 2019 https://doi.org/10.7554/eLife.36842.001
- Application stochastic simulations to mRNA splicing in human cells – 2020 https://doi.org/doi:10.1371/journal.pcbi.1007717
Links to Relevant Software:
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