q-bio Summer School and Conference, 2022

Helena Ma

 

Helena Ma

Duke University

Collaborators: Helen Xu, Duke University; Lingchong You, Duke University

Title: Evolutionary dynamics of combined antibacterial treatment

Short Abstract:  β-lactam antibiotics are administered in combination with β-lactamase (Bla) inhibitors to address Bla-mediated resistance. However, the factors governing the evolutionary consequences of Bla inhibitor use are still poorly understood. Using mathematical modeling and an engineered experimental system, we identify strain- and drug-specific factors that predict the evolutionary response of strains treated with β-lactam/Bla inhibitor combinations. Our results can guide clinicians in treating infections while minimizing resistance.

Link to Full Abstract: MA_HELENA

Link to Poster: Poster Helena Ma

Contact: helena.ma@duke.edu