Collaborators: Helen Xu, Duke University; Lingchong You, Duke University
Title: Evolutionary dynamics of combined antibacterial treatment
Short Abstract: β-lactam antibiotics are administered in combination with β-lactamase (Bla) inhibitors to address Bla-mediated resistance. However, the factors governing the evolutionary consequences of Bla inhibitor use are still poorly understood. Using mathematical modeling and an engineered experimental system, we identify strain- and drug-specific factors that predict the evolutionary response of strains treated with β-lactam/Bla inhibitor combinations. Our results can guide clinicians in treating infections while minimizing resistance.
Link to Full Abstract: MA_HELENA
Link to Poster: Poster Helena Ma