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The Virtual Cell project
From Q-bio
Leslie Loew (U Conn Health Center)
- Abstract
- Elaborate biochemical reaction networks control the activity of cells and their responses to environmental stimuli. The challenge of understanding the behavior of such networks can be guided by the predictions generated from kinetic models. But cells and their subcellular organelles have complex structures that provide a framework for the dynamic spatial distribution of signaling molecules. How this cellular architecture shapes and controls the response of cells to their environment must be incorporated in any attempt to understand a cellular process. The Virtual Cell is a computational modeling software environment that has been designed to address this need. The operation of the Virtual Cell will be illustrated with a new dynamic model of the actin cytoskeleton. (This work is supported by NIH Grants U54RR022232 and P41RR013186)
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