In this theme we will address a number of biological and mathematical issues related to modeling of evolution of cancer. Lectures will cover topics spanning many time- and length-scales, from the fundamental issues of cell proliferation and mutation dynamics, to molecular events affecting specific pathways in cells, to population genetics effects (see the abstracts further on). This section of the summer school will include a number of instructor-suggested group projects, in which students will apply various numerical techniques to formulate, identify and solve stochastic models of cancer evolution. Students will then apply these tools to model experimental and clinical data. This section of the summer school is organized by Marek Kimmel (firstname.lastname@example.org) and Rosemary Braun (email@example.com) -- please contact us if you have any questions!