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Open Complex Formation by Bacterial RNA Polymerase - a Quantitative Model
From Q-bio
Marko Djordjevic (MBI, Ohio state)
- Abstract
- Despite intensive research in the last two decades, the mechanism by which bacterial RNA polymerase (RNAP) forms open complex is still unknown. We here present the first quantitative model of open complex formation. We derive an explicit connection between transcription initiation rate and physical properties of the promoter sequence and promoter-RNAP interactions. We compare our model with both biochemical measurements and genomics data and report a very good agreement with experiments, with no free parameters used in model testing.
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