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Metabolic gene regulation in a dynamically changing environment
From Q-bio
Matthew R. Bennett, Wyming L. Pang, Natalie A. Ostroff, Lev S. Tsimring, and Jeff Hasty
- Abstract
- We monitor the response of S. cerevisiae metabolic gene regulation to periodic changes in the external carbon source. We find that the system acts as a low-pass filter that reliably responds to a slowly changing environment, while effectively ignoring fluctuations that are too fast for the cell to efficiently respond. We use computational modeling to determine that frequency selection in the system is controlled by the interaction of coupled positive feedback networks governing the signal transduction of alternative carbon sources. Our findings establish a framework for probing organisms to reveal the mechanisms that mediate cellular responses to unpredictable environments.
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