Knowledge Management for Translational Informatics Using the CARLSBAD Platform
BRIDGING the gap between finding treatments for unmet clinical needs and discoveries born at bench-side requires a novel approach built on integrated biological, chemical and medical knowledge. The recently developed platform, Confederated Annotated Research Libraries of Small-molecule Biological Activity Data (CARLSBAD), includes high quality chemical biology data that has been enhanced with biological pathway information of the KEGG database. The aim of this integration is to provide researchers and also clinical examiners with the opportunity to investigate scientific questions and explore possible treatments from top-bottom and bottom-up aspects in a target-pathway-disease hierarchy. The aim of this tutorial is to demonstrate how the KEGG extended CARLSBAD platform can be utilized effectively to perform knowledge management within a translational discovery setting.
Gergely Zahoranszky-Kohalmi, Jeremy J. Yang, Stephen Mathias, Oleg Ursu, Jarrett Hines-Kay, Cristian G. Bologa, and Tudor I. Oprea
Translational Informatics Division, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA Knowledge Management for Translational Informatics Using the CARLSBAD Platform
The CARLSBAD platform project was funded by NIH R21 grant 1R21GM095952-01 (TIO).