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How Cells Decide Between Apoptosis and Survival in Response to DNA Damage
From Q-bio
Gerard J. Ostheimer, Ericka Noonan, Andrea Tentner, Alexandra Gardino, Dharini Shah, Leona Samson, Michael B. Yaffe and Douglas A. Lauffenburger
- Abstract
- In response to DNA damage eukaryotic cells arrest their cell cycle and then either repair the damage and proliferate or cease to proliferate and apoptose or senesce. We are intrested in understanding how cells compute their fate in response to varying types and degrees of DNA damage. To do so we are quantitatively monitoring DNA damage signaling, the cell cycle machinery, the apoptotic machinery as well as mitogen/stress activated kinase pathways. These data will form the basis of models that will seek to characterize the cellular decision process in response to DNA damage.
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