Michael May is a 4th year Ph.D. Student in Biomedical Engineering and is currently co-advised by Dr. Munsky and Dr. Stasevish. He works on problems characterizing variability in single-cell, single-molecule experiments using computational and mathematical tools, and uses control theory derive new control techniques to control random processes. His current work is building an automated microscope that can eventually be used for the control of cell populations, and developing new control techniques for optogenetic controlled systems.

Title: Learn the meaning of the Chemical Master Equation, and the Finite State Project approach to analyze the distributions of single-cell behaviors

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Suggested Reading or Key Publications:

• • Munsky, B., Khammash, M., The Finite State Projection Algorithm for the Solution of the Chemical Master Equation, Journal of Chemical Physics, 124 :044104 (2006). reprint (.pdf) (Original Paper)
  • Munsky, B., Modeling Cellular Variability, in Quantitative Biology From Molecular to Cellular Systems, pp. 234-266, M. Wall, Ed. (Taylor & Francis Group, New York, 2012). preprint (.pdf) (Good review of method and examples of several models)

Links to Relevant Software: 

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• • Question 1
  • Question 2